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KMID : 0361920090390050337
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Korean Journal of Orthodontics
2009 Volume.39 No. 5 p.337 ~ p.347
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Stimulation of bone formation in the expanding inter-premaxillary suture by vitamin E, in rat
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Tancan Uysal
Mihri Amasyali
Huseyin Olmez
Yildirim Karslioglu
Omer Gunhan
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Abstract
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Objective: The aim of this study was to evaluate the effects of vitamin E (?-tocopherol) administration on bone formation in response to expansion of the inter-premaxillary suture, in rats, histomorphometrically.
Methods: Thirty 50 - 60 day old Wistar rats were separated into five equal groups (one control and four experimental). All groups were subjected to inter-premaxilla expansion with 50-gram of force. Six control animals received saline solution (Group I) and three experimental groups were treated with a single dose of ?-tocopherol injected into the inter-premaxillary suture after one day after appliance placement (Group II: 2 mg/kg; Group III: 10 mg/kg; and Group IV: 50 mg/kg). A further group of six animals received three injections of 10 mg/kg ?-tocopherol, one each on days 3, 6, and 9 (Group V). Bone formation in the suture was evaluated by bone histomorphometry. Kruskal-Wallis rank and Mann-Whitney U tests were used for statistical evaluation at p ＜ 0.05 level.
Results: New bone area, bone perimeter, feret’s diameter and newly formed bone measurements were significantly higher in the experimental groups than the control (p ＜ 0.001). Bone architecture in ?-tocopherol administrated groups was improved, and bone formation during the expansion period was stimulated significantly, in a dose-dependent manner.
Conclusions: The application of ?-tocopherol during the early stages to orthopedically expanded inter-premaxillary suture areas may stimulate bone formation and shorten the retention period, in rats.
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KEYWORD
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Vitamin E, ?-tocopherol, Expansion, Histomorphometry, Rat
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